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There were no deaths or serious adverse occasions connected with drug therapy in scientific trials involving 800 non-pregnant Gals who been given METROGEL-VAGINAL.
Disulfiram-like response to alcohol is described with oral metronidazole, thus the opportunity of such a reaction transpiring though on metronidazole vaginal gel therapy cannot be excluded.
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Patients with significant hepatic condition metabolize metronidazole slowly and gradually. This brings about the accumulation of metronidazole and its metabolites during the plasma. Accordingly, for these kinds of patients, metronidazole vaginal gel really should be administered cautiously.
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Oral metronidazole has been reported to potentiate the anticoagulant impact of warfarin along with other coumarin anticoagulants, leading to a prolongation of prothrombin time.